About HMRLab
Our research interests are centered around the development of new hyperpolarization approaches for preparing nuclear spins in highly polarized ‘or aligned’ states, typically yielding > 10’000 fold sensitivity enhancements in magnetic resonance (both NMR and MRI).
To put it simple we magnetize molecules and materials to augment their sensitivity in magnetic resonance.
We are spanning across disciplines, from Physics, Chemistry, Biochemistry, to Medicine. We conceive new methods and instrumentation, and ultimately provide powerful tools to solve challenges at the forefront of molecular and chemical sciences today.
HMRlab Team
Sami Jannin
Principal Investigator
James Tolchard
Research Engineer
Arianna Actis
PostDoc - HypFlow
Dahmane Boudries
PostDoc - Tryp
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Karen Dos Santos
PostDoc - Tryp
Ekaterina Pokochueva
PostDoc - HyperZulf
Charlotte Bocquelet
PostDoc - Hypflow
Nathan Rougier
PhD - HypFlow
Julien Dieterich
PhD - HypFlow
Yang Wang
PhD - HypFlow
Mohamed Ayman Ennachet
Enginner
Former members
Chloé Gioiosa
NMR Application Scientist at Annaida Technologies, Switzerland
Ewoud Vaneeckhaute
PostDoc at KU Leuven, Belgium
Eve Bricard
Engineer
Huu-Nghia Le
PostDoc at CPE Lyon, France
Sylvie Guibert
Engineer at Centre Commun de RMN
Lyon, France
Quentin Stern
PostDoc at Northwestern University (Swiss mobility Grant),
Chicago, USA
Gilles Rautureau
Professor at University of Lyon, France
Morgan Ceillier
Permanent contract in Industry
Montpellier, France
Olivier Cala
School Professor
Lourdes, France
Samuel Cousin
Permanent Researcher CNRS
Marseille, France
Stuart James Elliott
Permanent Scientist at Imperial College
London, UK
Théo El Darai
PostDoc at Toulouse, France
Ariana Ferrari
PhD Student
Kiel, Germany
Aurélien Bornet
Head of NMR service EPFL
Lausanne, Switerland
Jonas Milani
Permanent Scientist at Firmenich
Geneva, Switzerland
Basile Vuichoud
Head of the NMR team at Firmenich
Geneva, Switzerland
Scientific Projects
ERC PoC - Tryp
Technology development for hyperpolarization transport
ANR - TransHyp
Preclinical MRI with transportable hyperpolarization
ERC CoG - HypFlow
Replenishable Hyperpolarization by freeze-melt DNP in polarizing matrices
IUF
IUF project
ANR DFG - HyperZulf
Hyperpolarized Zero-Field NMR for reaction monitoring
ERC StG - HP4all
Generating transportable hyperpolarization with HYPOP matrices
ANR - HyMag
HYPSO hyperpolarizing matrices
CIFRE - TotalEnergies
Hyperpolarization for energy materials
Publications
Applications
Gioiosa, C. et al. Dissolution-DNP Enables the Detection of 13C Hyperpolarized NMR Spectra of Li-Ion Battery Electrolytes. ChemRxiv 2024
Cala, O. et al. Micromolar Concentration Affinity Study on a Benchtop NMR Spectrometer with Secondary13 C Labeled Hyperpolarized Ligands. ACS Omega 2025
A. Dey. et al. Hyperpolarized NMR Metabolomics at Natural 13C Abundance. Anal. Chem. 92, 22, 14867 (2020) (IF=6.9)
S. J Elliott. et al. Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups. PhysChemChemPhys 20, 9755, (2018)
Dumez, J. N. et al. Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups. J. Phys. Chem. Lett. 8, 3549-3555, (2017)
DNP agents/Materials
Stern, Q. et al. Dynamic Nuclear Polarization with Conductive Polymers. Angew Chem Int Ed 2024, e202409510.
Pokochueva, E. V. et al. Hybrid Polarizing Solids with Extended Pore Diameters for Dissolution Dynamic Nuclear Polarization. ChemRxiv 2024.
M. Negroni. et al. Frémy’s Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging. J. Am. Chem. Soc. 2022, 144, 45, 20680–20686
T. El Daraï and S. Jannin. Sample formulations for dissolution dynamic nuclear polarization. Chem. Phys. Rev., vol. 2, no. 4, p. 041308, 2021
M Cavaillès. et al. Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging. Angewandte Chemie 130, 7575, (2018)
Ji, X. et al. Overhauser effects in non-conducting solids at 1.2 K. Journal of magnetic resonance 286, 138-142, (2018)
Silverio, D. L. et al. Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls. Helvetica Chimica Acta 100, (2017)
HypFlow DNP
Vaneeckhaute, E. et al. Full Optimization of Dynamic Nuclear Polarization on a 1 Tesla Benchtop Polarizer with Hyperpolarizing Solids.Phys. Chem. Chem. Phys. 2024, 26 (33), 22049–22061
Bocquelet, C. et al. Boosting 1H and 13C NMR Signals by Orders of Magnitude on a Bench. Sci. Adv.10, eadq3780 (2024)
Hardware
S. J. Elliott. et al. Simple and Cost-Effective Cross-Polarization Experiments under Dissolution-Dynamic Nuclear Polarization Conditions with a 3D-Printed 1H-13C Background-Free Radiofrequency Coil. J. Magn. Reson. Open, 10, 100033 (IF=2.2)
M. Baudin. et al. A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T. J. Magn. Reson. 294, 115, (2018)
ZULF NMR
Quentin Stern. et al. Rapid and Simple 13C-Hyperpolarization by 1H Dissolution Dynamic Nuclear Polarization Followed by an Inline Magnetic Field Inversion. Journal of the American Chemical Society 2023 145 (50), 27576-27586 (IF = 16)
Román Picazo-Frutos. et al. Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization. Analytical Chemistry 2023 95 (2), 720-729 (IF = 8)
CP and dCP
S. J. Elliott. et al. Protonation-tuned dipolar order mediated 1H→13C cross-polarization for dissolution-dynamic nuclear polarization experiments. Solid-State Nucl. Magn. Reson., vol 116, 101762, 2021
S. J. Elliott. et al. Pulse sequence and sample formulation optimization for dipolar order mediated1H→13C cross-polarization. Phys. Chem. Chem. Phys., vol. 23, no. 15, pp. 9457–9465, 2021, (IF=3.9)
S. J. Elliott. et al. Boosting Dissolution-Dynamic Nuclear Polarization by Multiple-Step Dipolar Order Mediated 1H→13C Cross-Polarization. J. Magn. Reson. Open, p. 100018, Apr. 2021, (IF=2.2)
S. J. Elliott. et al. Dipolar order mediated 1H → 13C cross-polarization for dissolution-dynamic nuclear polarization. Magn. Reson. 1, 89, (2020).
Jonas Milani. et al. Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization. Rev. Sci. Instrum. 88 , 015109 (2017) (IF = 1.16)
Transport
T. El Daraï. et al. Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites, Nat. Commun., vol. 12, no. 1, pp. 1–9, (2021) (IF=14.9)
Xiao Ji. et al. Transportable hyperpolarized metabolites. Nat. Commun. 2017, 8, 13975 (IF = 11.3)
Theory
Vaneeckhaute, E. et al. Dynamic Nuclear Polarization Mechanisms Using TEMPOL and Trityl OX063 Radicals at 1 T and 77 K. The Journal of Chemical Physics, 2025, vol. 162, no 15
Elliott, S. J.; Stern, Q.; Jannin, S. 13C-Formate as an Indirect Low-Temperature 1H Lineshape Polarimeter. Journal of Magnetic Resonance Open 2024, 21, 100162
Alessandro Chessari, Samuel F. Cousin, Sami Jannin, and Quentin Stern. Role of electron polarization in nuclear spin diffusion. Phys. Rev. B 107, 224429 (IF = 3.7)
I. V. Koptyug, Q. Stern, S. Jannin, S. J. Elliott. Frozen water NMR lineshape analysis enables absolute polarization quantification. Phys. Chem. Chem. Phys., 2022, 24, 5956-5964
S. J. Elliott, Q. Stern, and S. Jannin. Solid-state 1H spin polarimetry by 13CH3 nuclear magnetic resonance. Magn. Reson., vol. 2, pp. 643–652, 2021
Q. Stern. et al. Direct observation of hyperpolarization breaking through the spin diffusion barrier. Sci. Adv., vol. 7, no. 18, pp. 1–14, 2021 (IF=14.1)
Reviews
James Eills. et al. Spin Hyperpolarization in Modern Magnetic Resonance. Chemical Reviews 2023 123 (4), 1417-1551(IF = 72)
S. J. Elliott. et al. Practical dissolution dynamic nuclear polarization. Prog. Nucl. Magn. Reson. Spectrosc., vol. 126–127, pp. 59–100, Oct. 2021, (IF=9.8)
S. Jannin, J. N. Dumez, P. Giraudeaub, D. Kurzbach. Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts. J. Magn. Reson. 305, 41, (2019)
K. V. Kovtunov. et al. Hyperpolarized NMR: d‐DNP, PHIP, and SABRE. Chemistry. An Asian Journal. 13, 1857, (2018)
B. Plainchont, P. Berruyer, J.-N. Dumez, S. Jannin, P. Giraudeau. Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry. Anal. Chem. 90, 3639, (2018)
